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Discovery of a characteristic molecular signature by microarray analysis of...

AbstractThe aim of this study was to determine the transcriptomic response in workers exposed to volatile organic compounds (VOCs). As blood is one of the most easily accessible sources of RNA for...

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Extraction method for manipulation of water- and organic-soluble extracts of...

AbstractParticulate matter (PM) air pollution is a significant environmental issue. PM is divided into three main fractions based on its size: coarse (2.5–10 μm), fine (0.1–2.5 μm), and ultrafine...

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Valproic acid inhibits cell size and cell proliferation by AMPK-mediated mTOR...

AbstractValproic acid is commonly used to treat seizure disorders, bipolar disorder, migraine prophylaxis, and neuropathic pain. Despite its effectiveness and widespread use, valproic acid has been...

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Integrated analysis of microRNA and mRNA expression profiles highlights...

AbstractWe have shown that aldehydes impact gene expression profiles of bronchial airway associated with pulmonary toxicity. In this study, we aimed to determine whether microRNA (miRNA) plays a role...

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Discovery of characteristic molecular signatures for the simultaneous...

AbstractGene expression data may be very promising for the classification of toxicant types, but the development and application of transcriptomic-based gene classifiers for environmental toxicological...

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Analysis of dose-response to hexanal-induced gene expression in A549 human...

AbstractThe problems of analyzing dose effects on gene expression are gaining attention in toxicological research. Determining how gene expression profiles change with toxicant dose will improve the...

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Adsorption of Ammonium Nitrogen and Phosphate onto Basanite and Evaluation of...

AbstractPure and surface-modified basanites (SMBs) were investigated for treatment of nutrients such as ammonium nitrogen and phosphate in aqueous solution. Basanite is a volcanic rock with a large...

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The effects of Di-2-ethylhexyl phthalates (DEHP) on the cell cycle of the...

AbstractIn this study, we evaluated the effects of Di-(2-ethyhexyl) phthalates (DEHP) on cell cycle. We cultured human endometiral cancer cell lines (ECC-1) and then incubated them for 48 h with 50 μM...

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Gene expression profiling of human alveolar epithelial cells (A549 cells)...

AbstractMany epidemiological and in vitro studies have shown that particulate matter 2.5 (PM2.5) is associated with adverse health effects in humans, especially respiratory morbidity and mortality1–3....

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Effective Treatment of Nutrients by Adsorption onto the Surface of a Modified...

AbstractA pure clay ball and surface-modified clay ball were investigated to remove phosphate from synthetic wastewater; phosphate causes eutrophication in hydro-ecological systems. Adsorption tests of...

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Hexanal-induced changes in miRNA-mRNA interactions in A549 human alveolar...

AbstractAlthough hexanal is considered to be a major air pollutant the correlation between hexanal and health risk is largely unknown. Identifying aldehyde toxicity in eukaryotic cells will be useful...

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Dose-response analysis of the effects of persistent organic pollutants (POPs)...

AbstractDetermination of gene expression profile alterations following dose-dependent exposure to toxicants will greatly improve the utility of arrays in identifying biomarkers and elucidating modes of...

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Analysis of gene expression changes in relation to hepatotoxicity induced by...

AbstractPerfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) represent a rising class of persistent organic pollutants termed perfluorinated chemicals (PFCs). In this study, hepatotoxic...

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Transcriptomic change as evidence for cadmium-induced endocrine disruption in...

AbstractWe evaluated cadmium (Cd)-induced acute toxicity in Oryzias javanicus (marine medaka or Javanese ricefish) and gathered transcriptomic evidence for the Cd-induced endocrine-disrupting effect....

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Expression of exosomal and cellular microRNAs: as biomarkers for toluene,...

AbstractExosomes, small vesicles released by many cells, are associated with various biological processes and they can potentially be used for prognosis and therapy and as biomarkers of health. Thus,...

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Investigation of the genetic toxicity by dextran-coated superparamagnetic...

AbstractDextran-coated superparamagnetic iron oxide nanoparticles (dextran-SPION) have been commercially used for medical applications, such as magnetic imaging or targeted drug delivery, etc. Despite...

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A study of cytotoxicity and genotoxicity of particulate matter (PM 2.5 ) in...

AbstractBackgroundsExposure to airborne particulate matter (PM2.5), a PM with an aerodynamic diameter of less than 2.5 μm, is known to be associated with a variety of adverse health effects,...

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The genome of the giant Nomura’s jellyfish sheds light on the early evolution...

AbstractBackgroundUnique among cnidarians, jellyfish have remarkable morphological and biochemical innovations that allow them to actively hunt in the water column and were some of the first animals to...

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Association of expression of GADD family genes and apoptosis in human kidney...

AbstractBackgroundNephrotoxicity is often referred to as a side effect of most drugs, but methods for effectively detecting nephrotoxicants still require development.ObjectiveIn this study, we...

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DNA Methylome Analysis of Saturated Aliphatic Aldehydes in Pulmonary Toxicity

AbstractRecent studies have investigated the epigenetic effects of environmental exposure to chemicals on human health. The associations of DNA methylation, environmental exposure and human diseases...

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